Dr. David E. Samaniego attended and graduated from Loma Linda University in 1996. From 1993 to 1996 he attended several mission trips as part of his education in dentistry, each a minimum of six weeks long. In these trips, he volunteered dental work in association with Doctors Without Borders and ADRA. The mission trips covered several areas of Mexico, including Baja California and Chiapas.
In 1995, he undertook a three-month medical journey to South America in the Amazon jungles of Brazil.
In 1996, Dr. David Samaniego joined his brother, Dr. Mario Samaniego, at Las Cruces Dental Associates.